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KMID : 0372919860070020111
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Journal of Biomedical Engineering Research
1986 Volume.7 No. 2 p.111 ~ p.112
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Development of Hollow Fibers for the Controlled Release of Drugs
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Feijen J
Eenink MJD/Olijslager J/Schakenraad JM/Nieuwenhuis P/Molenaar I
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Abstract
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Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100,300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise.
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KEYWORD
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